Gluvan Plus | Vildagliptin 50 + Metformin Hydrochloride 500 | Price
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Home Diabetic Care Diabetes Medicines Gluvan Plus | 50+500mg Tablet | 1 Strip

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Gluvan Plus | 50+500mg Tablet | 1 Strip

Generic: Metformin Hydrochlorida + Vildagliptin

Type: Tablet

Pack Size: 10 Pcs

Vildagliptin + Metformin Hydrochloride is prescribed alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus who are not adequately managed on Metformin Hydrochloride or Vildagliptin alone, or who are already receiving both drugs separately.

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✅ Description:

Vildagliptin works by inhibiting the enzyme DPP-4 (Dipeptidyl peptidase-4), which breaks down incretin hormones like GLP-1 and GIP. This inhibition boosts levels of these hormones, leading to increased insulin release from pancreatic beta cells and reduced glucagon release from alpha cells, particularly during high blood sugar, thereby lowering glucose production in the liver and reducing blood sugar levels.

Metformin Hydrochloride, a biguanide oral antidiabetic, lowers both fasting and post-meal glucose without causing hypoglycemia. It works by reducing glucose production in the liver, decreasing glucose absorption in the intestines, and enhancing insulin sensitivity to improve glucose uptake and use in tissues.

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✔️ Side Effects

Common effects include headache, dizziness, tremor, nausea, and low blood sugar.

✔️ Dosage & Administration:

Adults: Dose depends on the patient’s current Metformin regimen. Typically taken twice daily—one tablet in the morning and one in the evening—with food to reduce gastrointestinal side effects. Patients switching from separate tablets may start with equivalent doses in the combination form. Daily vildagliptin dose should not exceed 100 mg. No clinical data support triple therapy with other antidiabetics.

Children: Not recommended under 18 years.

Elderly: Monitor kidney function regularly; use only if renal function is normal.

Renal impairment: Avoid if serum creatinine >1.5 mg/dL (men) or >1.4 mg/dL (women).

Hepatic impairment: Not recommended if baseline liver enzymes are >3× upper normal limit.

✔️ Drug Interactions

No significant interaction between vildagliptin and metformin has been found. Vildagliptin is not metabolized by, nor does it affect, CYP450 enzymes, so it is unlikely to interfere with drugs processed by this pathway. It shows no major interactions with common medications like glibenclamide, pioglitazone, amlodipine, digoxin, ramipril, simvastatin, valsartan, or warfarin. However, drugs like furosemide, nifedipine, and glyburide can raise metformin levels in the blood without affecting its kidney clearance.

✔️ Contraindications:

Not to be used in patients allergic to either component, with kidney disease or dysfunction, acute myocardial infarction, septicemia, heart failure, or metabolic acidosis (including diabetic ketoacidosis). Avoid in those undergoing imaging with iodinated contrast, as it may cause sudden kidney issues.

✔️ Pregnancy & Lactation

Use only if potential benefits outweigh risks, as safety in pregnancy is unproven. It is unknown if the drugs pass into breast milk; therefore, avoid during breastfeeding.

✔️ Precautions & Warnings

Risk of lactic acidosis from metformin accumulation—stop treatment immediately if suspected and hospitalize the patient. Monitor kidney function annually (more often in elderly or borderline cases). Liver function tests should be checked before starting, every 3 months in the first year, and periodically thereafter. Discontinue if persistent liver enzyme elevation or signs of liver damage occur. Stop treatment 48 hours before surgery with general anesthesia and restart only after at least 48 hours.

✔️ Storage

Store in a cool, dry place, away from heat and light. Keep out of children’s reach.

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Check our pricing section for Gluvan Plus | 50+500mg Tablet | 1 Strip price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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